Their mission is simple: Find a cure. Stop the virus. Save the world. When a global pandemic wipes out eighty percent of the planet's population, the crew of a lone and unaffected Navy destroyer, the USS Nathan James, must find a way to pull humanity from the brink of extinction.
56 listed episodes across 5 seasons. Air dates are provided by TVmaze and can change.
Season 1 10 episodes
E01
Phase Six
Captain Tom Chandler and the crew of the USS Nathan James set out for the Arctic with two civilian virologists, Dr. Rachel Scott and Dr. Quincy Tophet, who claim to be studying birds. When they come under attack by a renegade team of Russian forces, Chandler learns these virologists are actually collecting samples of the source of a deadly virus that has wiped out over half the human population while they've been at sea. As they head home on the orders of the remaining U.S. government, Chandler and his crew realize that home is a shadow of what they left, and the safest place to develop a vaccine for this deadly disease is out at sea on thei…
E02
Welcome to Gitmo
Chandler and his crew head to the U.S. Military base at Guantanamo Bay in hopes of collecting food, medical supplies and fuel replenishments. Three teams are dispatched to carry out these varied tasks. While there, they come under attack by escaped Gitmo prisoners and enlist the help of a grizzled private contractor who's been surviving for weeks and living off the land.
E03
Dead Reckoning
The James faces off against a new foe who demands Chandler hand over Rachel and her research. When Chandler refuses, he and his crew are put to the test as Chandler engages in a series of risky strategic moves. But it turns out their new enemy has his own horse in the race to find a cure for the virus.
E04
We'll Get There
Days after a trying series of events at Gitmo, Chandler and his crew are put under extreme duress when the ship's propulsion system suffers a catastrophic event. With Dr. Scott in danger of losing all her research on the virus and a crew overworked, overtired and desperately low on drinking water, Chandler's leadership and ingenuity are put to the test.
E05
El Toro
With Rachel close to a breakthrough on her vaccine, she, Chandler and XO Slattery lead a small team into the jungles of Nicaragua on a mission to find monkeys for her vaccine trials. While there, they find much more than they bargained for when they run across a former drug kingpin who will stop at nothing to maintain his stranglehold on his oppressed society. Chandler and his men find themselves in a huge moral dilemma over whether to eliminate this menace or take what they need and continue on with their mission.
E06
Lockdown
After returning from the horrors of Nicaragua, panic begins to spread throughout the ship when Lt. Danny Green comes down with a mysterious illness that could be the virus. Losing faith in Rachel and her failing vaccine trials, Chandler now has to deal with a restive crew. If he fails to keep the crew together, the whole mission is in jeopardy.
E07
SOS
After picking up a distress call near Jamaica, Chandler and a small team stage a rescue attempt. But a surprise attack leaves Chandler and Tex stranded at sea. Slattery and the crew search desperately to find their lost at sea Captain and his comrade, hoping to do so before their enemies beat them to it.
E08
Two Sailors Walk Into a Bar
With Chandler and Tex caught in a dangerous situation, Slattery has to step into the role as commanding officer. Torn between a mission with the fate of the world at stake and a Captain in danger, Slattery has to find a way to get his people back without losing the most important asset: the vaccine prototype.
E09
Trials
Rachel and Chandler ask for six volunteers to participate in human trials of her vaccine, but the tests could be a living hell as the virus and the vaccine do battle inside their bodies. Meanwhile back in the States, Chandler's wife and father are doing everything they can to keep their family alive.
E10
No Place Like Home
Chandler and his crew finally return home, where a former D.C. power player is fending off a dangerous warlord who threatens everyone's hopes of restoring law and order in society. Now with a location and a means to finalize their mission, Chandler sets out to find his family, only to discover something absolutely terrifying about this brave new world.
Season 2 13 episodes
E01
Unreal City
After the horrifying revelations and reversals of fortune in Baltimore, Chandler and his fractured team join forces with an underground resistance in an attempt to defeat Amy Granderson. With doses of the cure running low, Rachel tries to do some good for the sick while remaining a prisoner at Avocet. Meanwhile, Slattery and the crew of Nathan James are in a race against time to save an injured Dr. Tophet and regain control of their ship.
E02
Fight the Ship
Rachel tries to help the sick while remaining a prisoner; Slattery and the crew try to regain control of their ship.
E03
It's Not a Rumor
Nathan James returns home to Norfolk on a mission to produce and mass distribute the cure. With his family now safely aboard the James, Chandler sends his crew in search of their own friends and loved ones. Who, if any, will find their families? And will those who do return to the ship?.
E04
Solace
The crew of Nathan James discovers that hospital ship USNS Solace was sent to sea to wait for Dr. Scott's cure. Captain Chandler sees an opportunity to add another ship to their fleet while Rachel is eager to find a lab better equipped to replicate the vaccine. When Solace fails to respond to radio communications, Chandler and his team board the ship..and come face-to-face with an unexpected enemy.
E05
Achilles
With a small group of survivors from Solace in tow, Chandler and his crew square off against an enemy of the most dangerous kind - a nuclear-powered submarine led by rogue British naval officers, Sean and Ned Ramsey. XO Slattery interrogates a captured mercenary from the hospital ship in an effort to extract information on the sub and its mission. As Nathan James engages in a perilous game of cat-and- mouse, the truth about the mercenary sub unfolds.
E06
Long Day's Journey
Chandler tracks the immunes to Northern Florida; Rachel comes across a secret formula that her mentor was working on; Chandler's team locates an immune compound.
E07
Alone and Unafraid
Slattery struggles to evade the sub; Chandler and the land team infiltrate the immune compound; Danny discovers that Niels is working for the Ramseys; Chandler manages to encroach Sean's inner circle.
E08
Safe Zone
While trying to piece together Dr. Hunter's lost formula, Rachel deals with the fact that her sworn enemy is on board the ship; Chandler tries to reverse the brainwashing Michener suffered at the hands of the Ramseys.
E09
Uneasy Lies the Head
With Dr. Scott on the verge of a breakthrough, Chandler and his team set out to land in search of much needed supplies and materials for her lab. Once there, Burk stumbles upon a gang of children who have been offered a bounty by the Immunes for information on the U.S. Navy. A vicious battle ensues when the Immunes come to collect their prisoners. Back on the ship, Rachel's efforts to produce a spreadable cure depend on Niels - her success now inextricably linked to the scientist who nearly erased mankind.
E10
Friendly Fire
Rachel is hard at work on a new, more efficient version of the cure while Alisha decodes a message found on a cell phone recovered from the Immunes on land. A suspicious death on the ship forces Chandler to launch a murder investigation, causing dissent among the crew and threatening to upset good order and discipline. Armed with new information provided by Michener, Nathan James heads to New Orleans, only to find that the Immunes have a terrifying surprise in store for them there.
E11
Valkyrie
Sean Ramsey broadcasts a message implicating the Navy in a devastating disaster. It's now more important than ever for Chandler to infiltrate their network and regain the trust of the American people. Nathan James locates the source of the Immune's signal - a mysterious oil platform in the middle of the ocean. Once there, Chandler and his team engage in a brutal battle with civilian forces who have aligned themselves with the Ramsey's plan.
E12
Cry Havoc
After retrieving the mastermind behind the Immune communications network, Nathan James finds itself trapped between the sub and civilian blockades set up by the Immunes. Chandler sends Dr. Scott and the cure off the ship under the protection of XO Slattery as the James heads towards its inevitable final showdown with the sub.
E13
A More Perfect Union
With their mission now fully dedicated to spreading the cure, Nathan James puts a call out to civilians to meet at pre-selected ports across the country, where all will receive the cure. However, small Immune factions remain active in their quest to fight the cure and fulfill Ramsey's dreams. Will Nathan James regain America's trust? Has the havoc and destruction caused by the Immunes ended all hope to spread the cure? Or will Nathan James prevail against the enemy and finally spread the cure?.
Season 3 13 episodes
E01
The Scott Effect
CNO Tom Chandler is sent to Asia to investigate a possible mutation of the Red Flu. Captain Slattery and his crew deliver cure to Southeast Asia but there may be an unexpected threat in the region.
E02
Rising Sun
Chandler must find a way to return to his old crew and investigate a dangerous new foe.
E03
Shanzhai
Chandler and crew race to find answers in an Asian Dodge City. Slattery begins to unravel the truth about his troubling predicament.
E04
Devil May Care
Chandler must confront his suspected new foe. Slattery learns more about the supposed virus mutation. Pressure mounts on President Michener as the situation worsens
E05
Minefield
Chandler's mission becomes complicated as his position is worsened. President Michener faces pressure from the regional leaders
E06
Dog Day
Chandler's mission comes to a head as he prepares the final part of his plan. President Michener ponders the fate of his presidency.
E07
In the Dark
The Nathan James must evade an overwhelming threat. A revelation in St. Louis puts President Michener in a terrible position.
E08
Sea Change
America copes with tragedy while Chandler further investigates the possible virus mutation.
E09
Paradise
Chandler gets a lead that could help answer threatening questions. Kara does some digging in the White House.
E10
Scuttle
Chandler finds himself faced with a difficult decision when a strange order comes in from the White House.
E11
Legacy
Chandler comes face to face with his powerful enemy in a final showdown. Kara joins up with someone that can help with her mission.
E12
Resistance
Chandler returns to America to find out what has really been happening.
E13
Don't Look Back
The fight for America comes to an end; Chandler faces a challenge that could change his life forever.
Season 4 10 episodes
E01
In Medias Res
Sixteen months after thwarting the coup in America, Nathan James must face yet another global disaster. The question remains, where in the world is Tom Chandler?
E02
The Pillars of Hercules
Having lost their only lead, the crew of Nathan James continues their search for an item that could save the world. Chandler immerses himself in a mission for revenge.
E03
Bread & Circuses
Nathan James's crew searches for a precious item leading them to a strange place of opulence and violence where they cross paths with a most unexpected ally.
E04
Nostos
The crew searches for one of their own as enemies close in on all sides. Slattery is haunted by visions of the past.
E05
Allegiance
Nathan James is diverted from their mission when they receive a suspicious distress call from a fishing trawler.
E06
Tempest
With an enormous storm on the horizon, Nathan James must navigate an equally terrifying threat in order to make it to safety.
E07
Feast
The search continues with a reconnaissance mission but things turn violent when an old foe resurfaces.
E08
Lazaretto
An undercover mission in the land of the dead leads to disturbing revelations about Dr. Vellek's sinister plans.
E09
Detect, Deceive, Destroy
The crew of Nathan James faces a threat that will test the limits of their Naval tactics and strategies.
E10
Endgame
Chandler confronts his enemy — and his personal demons — in a final showdown, with the fate of humanity on the line.
Season 5 10 episodes
E01
Casus Belli
Three years after overcoming the global famine, the United States Navy is ready to unveil its first fully functional fleet since the Red Flu pandemic, but a new type of threat may mean the next world war.
E02
Fog of War
Thrust back to World War II era military technology, Nathan James must think fast to survive a fight with limited weapons capabilities.
E03
El Puente
With nations being rapidly occupied, Chandler tries his hand at diplomacy to unite two hostile countries so they can fight a common enemy.
E04
Tropic of Cancer
As Nathan James and her allies attempt to prevent the enemy moving north, Chandler's haunting visions manifest into reality.
E05
Warriors
After months of fighting, the crew of Nathan James must embark on a dangerous mission to secure important intel that could decide the fate of the war.
E06
Air Drop
Nathan James must seek the aide of a prominent rebel leader in order to create a staging area before mounting an invasion of their own.
E07
Somos la Sangre
Pinned down after days of fighting, Vulture team must find their way into a secretive enemy camp.
E08
Honor
With a devastating hostage situation occurring back home, Chandler must devise the perfect plan to avoid losing everything.
E09
Courage
The crew of Nathan James begin preparations for what may be their most ambitious mission to date.
E10
Commitment
It is all out war as Chandler must face his fears and confront the greatest threat he has ever encountered.Series finale
